---
_id: '6976'
abstract:
- lang: eng
  text: "                  Chemoenzymatic processes have been gaining interest to
    implement sustainable reaction steps or even create new synthetic routes. In this
    study, we combined Grubbs’ second-generation catalyst with pig liver esterase
    and conducted a chemoenzymatic one-pot process in a tandem mode. To address sustainability,
    we encapsulated the catalysts in biopolymer hydrogel beads and conducted the reaction
    cascade in an aqueous medium. Unfortunately, conducting the process in tandem
    led to increased side product formation. We then created core-shell beads with
    catalysts located in different compartments, which notably enhanced the selectivity
    towards the desired product compared to homogeneously distributing both catalysts
    within the matrix. Finally, we designed a specific large-sized bead with a diameter
    of 13.5 mm to increase the diffusion route of the Grubbs’ catalyst-containing
    shell. This design forced the ring-closing metathesis to occur first before the
    substrate could diffuse into the pig liver esterase-containing core, thus enhancing
    the selectivity to 75%. This study contributes to addressing reaction-related
    issues by designing specific immobilisates for chemoenzymatic processes.\r\n                "
article_number: '547'
article_type: original
author:
- first_name: Jan
  full_name: Pauly, Jan
  last_name: Pauly
- first_name: Harald
  full_name: Gröger, Harald
  last_name: Gröger
- first_name: 'Anant V. '
  full_name: 'Patel, Anant V. '
  id: '201870'
  last_name: Patel
citation:
  alphadin: '<span style="font-variant:small-caps;">Pauly, Jan</span> ; <span style="font-variant:small-caps;">Gröger,
    Harald</span> ; <span style="font-variant:small-caps;">Patel, Anant V. </span>:
    Developing Multicompartment Biopolymer Hydrogel Beads for Tandem Chemoenzymatic
    One-Pot Process. In: <i>Catalysts</i> Bd. 9, MDPI (2019), Nr. 6'
  ama: Pauly J, Gröger H, Patel AV. Developing Multicompartment Biopolymer Hydrogel
    Beads for Tandem Chemoenzymatic One-Pot Process. <i>Catalysts</i>. 2019;9(6).
    doi:<a href="https://doi.org/10.3390/catal9060547">10.3390/catal9060547</a>
  apa: Pauly, J., Gröger, H., &#38; Patel, A. V. (2019). Developing Multicompartment
    Biopolymer Hydrogel Beads for Tandem Chemoenzymatic One-Pot Process. <i>Catalysts</i>,
    <i>9</i>(6). <a href="https://doi.org/10.3390/catal9060547">https://doi.org/10.3390/catal9060547</a>
  bibtex: '@article{Pauly_Gröger_Patel_2019, title={Developing Multicompartment Biopolymer
    Hydrogel Beads for Tandem Chemoenzymatic One-Pot Process}, volume={9}, DOI={<a
    href="https://doi.org/10.3390/catal9060547">10.3390/catal9060547</a>}, number={6547},
    journal={Catalysts}, publisher={MDPI}, author={Pauly, Jan and Gröger, Harald and
    Patel, Anant V. }, year={2019} }'
  chicago: Pauly, Jan, Harald Gröger, and Anant V.  Patel. “Developing Multicompartment
    Biopolymer Hydrogel Beads for Tandem Chemoenzymatic One-Pot Process.” <i>Catalysts</i>
    9, no. 6 (2019). <a href="https://doi.org/10.3390/catal9060547">https://doi.org/10.3390/catal9060547</a>.
  ieee: J. Pauly, H. Gröger, and A. V. Patel, “Developing Multicompartment Biopolymer
    Hydrogel Beads for Tandem Chemoenzymatic One-Pot Process,” <i>Catalysts</i>, vol.
    9, no. 6, 2019.
  mla: Pauly, Jan, et al. “Developing Multicompartment Biopolymer Hydrogel Beads for
    Tandem Chemoenzymatic One-Pot Process.” <i>Catalysts</i>, vol. 9, no. 6, 547,
    MDPI, 2019, doi:<a href="https://doi.org/10.3390/catal9060547">10.3390/catal9060547</a>.
  short: J. Pauly, H. Gröger, A.V. Patel, Catalysts 9 (2019).
date_created: 2026-06-02T09:04:19Z
date_updated: 2026-09-07T11:21:06Z
department:
- _id: '103'
doi: 10.3390/catal9060547
intvolume: '         9'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
oa: '1'
publication: Catalysts
publication_identifier:
  eissn:
  - 2073-4344
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: Developing Multicompartment Biopolymer Hydrogel Beads for Tandem Chemoenzymatic
  One-Pot Process
type: journal_article
user_id: '231260'
volume: 9
year: '2019'
...